Dhruba grew up in an environment where his father Pandit Nikhil Ghosh, the renowned percussionist, rehearsed his art and other renowned musicians frequented the home regularly like Ustad Ahmedjan Thirakwa (tabla), Ustad Amir Khan (vocal), Pandit Ravi Shankar (sitar), Ustad Ali Akbar Khan (sarod), Nikhil Banerjee (Sitar) and others of that era. As Dhruba absorbed the exhaustive discussions between the maestros and the performance of traditional repertoire, he began intensive instruction in voice and tabla under his father.
Later he became the student of Ustad Sagiruddin Khan (sarangi), the renowned disciple of Ustad Bundu Khan of the Delhi Gharana. Therefore by custom Dhruba belongs to the Delhi Gharana of Sarangi. Subsequently, he began receiving training from the veteran vocalist of the Agra Gharana Pt. Dinkar Kaikini. He has also been receiving fundamental gharana instruction from Ustad Ali Akbar Khan.
In European countries he has staged perfromances at the Bratislava International Music Festival, Helsinki International Music Festival, Flanders International Music Festival, Baroque Music Festival- Brussels, Silk Route Festival at Athens. He often performs in the US and Japan. He has accompanied renowned vocalists like Ustad Salamat Ali Khan, Ustad Ghulam Mustapha Khan, ustad Munawwar Ali Khan, Pt. Dinkar Kaikini, Smt. Shobha Gurtu, Smt Girija Devi and several others .
Dhruba started travelling as a sarangi player since 1974 on his father's concert tours and presented shows in Europe, US, Canada, Australia and the Far East. Since 1991 he has been touring solely as a solo player and also performs at collaboration concerts.
He has been at the centre of the creation of a World String Orchestra in Japan relating to the heritage bowed instruments of Japan, China, Korea, Uzbekistan and India. He has been fruitfully associating with western classical musicians like Phillipe Pierlot (Viola da Gamba), Jean Paul Dessy (cello), Francois Deppe (cello), Justin Pearson (cello), Yamashita (Jazz - Piano), world music artistes like Trilok Gurtu and Techno composer Robert Miles.
o "Soulful Sarangi" - Shree Raga, Tilak Kamod, Bihag, Bahar
o Yaman, Hemant
o Kaushi Kanada, Kajri
o Jaijaivanti, Mishra Khamaj Thumri
o Multani, Puriya, Kedara, Piloo thumri, Baul Song
o Komal Rishabh Asavari,
o Dhun - Basant Mukhari
o "Bowing Sounds From Dawn To Moonlight" - Ramkali, Shuddha Sarang, Marva, Hamir, Kafi Thumri
o “Dakshini” - Sajana Tuma Aao in Charukeshi
o Tarasa in Kirwani
o Basant Mukhari at 5 am in Paris”